At MEB Pharma Private Limited, we have developed our manufacturing and analytical infrastructure around one objective:

To manufacture spherical pellet platforms with consistent and measurable quality.

Our facility combines controlled manufacturing areas, specialized pellet-processing equipment and dedicated Analytical, Wet Chemistry and Microbiology Laboratories.

This integrated infrastructure enables us to monitor important quality attributes from raw-material evaluation through manufacturing, testing and finished-product release.

Our capabilities support the development and commercial manufacture of pharmaceutical and nutraceutical starter pellets, functional Starter / Core Pellets and spherical carrier systems.

Advanced Particle Characterization

Measuring Particle Size and Particle Shape with Precision

Particle size and particle shape are critical attributes for Starter / Core Pellets because they can influence drug/active-ingredient loading, coating behaviour, flow, packing and downstream processing.
MEB Pharma is equipped with a CAMSIZER® P4 dynamic particle analysis system for detailed particle-size and particle-shape characterization.

The CAMSIZER® P4 uses dynamic image analysis and provides a measurement range of approximately 20 µm to 30 mm for suitable dry, free-flowing materials. The system provides real-time analysis at up to 60 images per second, supports particle-shape analysis and enables reliable detection of oversized particles. Its particle-size results are compatible with conventional sieve-analysis results.

Critical Parameters Characterized

• Particle Size Distribution (PSD)
• Particle Size
• Particle Shape
• Sphericity / Roundness
• Aspect Ratio
• Oversized Particle Detection
• Batch-to-Batch Particle Consistency

Why It Matters

For multiparticulate dosage forms, pellet geometry and particle-size distribution can influence coating uniformity, loading behaviour and downstream processing.

CAMSIZER® P4 enables us to replace subjective visual assessment with quantitative particle characterization.

From “Looks Spherical” to “Measured Sphericity”

Our approach is simple:

Measure → Analyze → Compare → Control

This supports greater confidence in pellet consistency during formulation development and commercial manufacturing.

Pellet Mechanical Strength
Evaluating Pellet Robustness for Consistent Downstream Processing

Starter / Core Pellets experience mechanical stress during manufacturing, coating, transfer, handling, transportation and downstream processing. Maintaining appropriate mechanical robustness is therefore an important consideration for consistent pellet performance.

MEB Pharma is equipped with an Electrolab EGF-1 Granule Friability Tester for quantitative evaluation of granule and pellet friability.

Applicable pellet batches are evaluated against established product specifications and quality-control procedures to assess their resistance to abrasion and mechanical attrition.

 

What We Monitor

• Friability
• Mechanical robustness
• Generation of fines
• Pellet breakage
• Batch-to-batch consistency

Customer Benefits

Better mechanical robustness can support:

• Reduced pellet breakage
• Lower fines generation
• Better material recovery
• More consistent coating and handling
• Improved downstream processing
• Potentially improved overall process yield

By controlling pellet friability, MEB Pharma aims to minimize material loss and fines generation, supporting consistent processing efficiency and improved material recovery.

 

Precision Polarimetric Analysis

Analytical Control for Optically Active Materials

MEB Pharma is equipped with an Anton Paar MCP 100 Modular Compact Polarimeter for analytical measurement of applicable optically active materials.

The MCP 100 supports:

• Optical Rotation
• Specific Rotation
• % Concentration

The instrument provides a measurement range of ±89.9°, with 0.001° resolution and a standard wavelength of 589 nm.

Why It Matters

For applicable sucrose-based and other optically active materials, polarimetric analysis provides an additional analytical tool for evaluating identity, consistency and concentration-related attributes according to the relevant product specification..

MEB Pharma’s Quality Control laboratory is equipped with "Agilent Technologies 1260 Infinity II HPLC" for the precise separation and evaluation of *sucrose, dextrose, maltose, fructose and lactose*.

Chromatographic resolution is assessed against the "applicable pharmacopeial nutraceutical requirement and approved analytical method, including", supporting consistent quality and batch-to-batch control.

In-House Analytical Laboratory
Quality Testing Under Our Own Control

MEB Pharma has an in-house Analytical Laboratory supporting routine quality evaluation of our products.

Having analytical capabilities within our facility enables closer integration between: Manufacturing → Testing → Data Review → Quality Decision

Our laboratory supports applicable testing for:

• Raw Material Evaluation
• In-Process Testing
• Finished Product Testing
• Batch Release
• Product Development
• Process Optimization
• Customer Sample Evaluation

Testing is performed according to approved specifications, validated/qualified methods where applicable and established quality-control procedures.

MEB Pharma maintains an in-house Microbiology Laboratory to support applicable microbiological quality monitoring.

The laboratory supports relevant microbiological testing and monitoring activities in accordance with established procedures and applicable product requirements.

This provides closer control over microbiological quality throughout the manufacturing and quality-control process.

Integrated Quality Approach

From Raw Material to Finished Pellet

Our infrastructure enables an integrated approach to pellet manufacturing and quality evaluation.

01 — RAW MATERIAL CONTROL

Raw materials are evaluated according to established specifications before use.

02 — CONTROLLED MANUFACTURING

Pellet manufacturing is carried out using defined process parameters and controlled production conditions.

03 — PARTICLE CHARACTERIZATION

Particle size and particle-shape characteristics are evaluated using advanced particle- analysis technology, where applicable.

04 — MECHANICAL STRENGTH TESTING

Friability is evaluated against established product requirements.

05 — ANALYTICAL & MICROBIOLOGICAL TESTING

Applicable quality attributes are evaluated through our in-house laboratories.

06 — QUALITY REVIEW

Analytical results and batch documentation are reviewed against approved specifications.

07 — PRODUCT RELEASE

Products meeting the applicable approved specifications are released for supply.

Designed for Pharmaceutical & Nutraceutical Applications

Our infrastructure supports the development and manufacture of:

SPHIRO™ SS
Sugar Spheres
SPHIRO™ SG
Sugar Globules
SPHIRO™ M
MCC Pellets
SPHIRO™ MT
Mannitol Pellets
SPHIRO™ T
Tartaric Acid Pellets

These platforms can support applications including active-ingredient layering, functional coating and multiparticulate dosage-form development, subject to formulation requirements.

 

Why Partner With MEB Pharma?
Specialized Starter / core Pellet Manufacturing

Our infrastructure is focused on spherical pellet platforms rather than being a general-purpose pharmaceutical and nutraceutical manufacturing facility.

Advanced Particle Characterization
We quantitatively evaluate critical particle attributes using CAMSIZER® P4 technology.

In-House Quality Testing

Analytical, Wet Chemistry and Microbiology capabilities provide integrated quality oversight.

Process-Focused Manufacturing

Our equipment and infrastructure are designed around the requirements of pellet production, layering and coating.

Development-to-Commercial Capability

Our objective is to support customers beyond sampling — through formulation development, qualification, scale-up and long-term commercial supply.

Technology You Can Measure. Quality You Can Evaluate.

Your Pellet Manufacturing Partner

At MEB Pharma, we believe that consistent pellet quality begins with controlled manufacturing and measurable critical attributes.

Our infrastructure brings together:
Specialized Starter/Core Pellet Processing
+
Advanced Particle Characterization
+
Friability Testing
+
Analytical Laboratory
+
Wet Chemistry Laboratory
+
Microbiology Laboratory

to support reliable pharmaceutical and nutraceutical pellet manufacturing.

Looking for a Reliable Source of Starter Pellets?

Share your product, particle-size and application requirements with our technical-commercial team.

MEB Pharma Private Limited

Specialized Spherical Platforms for Pharmaceutica & Nutraceutical Formulation